The significance of Howell-Jolly bodies and giant metamyelocytes in marrow smears
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منابع مشابه
The significance of Howell-Jolly bodies and giant metamyelocytes in marrow smears.
Howell-Jolly bodies in erythroid precursors can be found in the marrow in a variety of diseases. More than 1% in the later erythroblasts is rarely found except in vitamin B(12) or folic acid deficiency states.Giant metamyelocytes are probably always the result of vitamin B(12) or folic acid deficiency. A distinction is drawn between the deficiency of, and therapeutic need for, vitamin B(12) and...
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During the routine examination of sternal marrow smears it was observed that the presence of nuclear fragments in red cell precursors, commonly known as Howell-Jolly bodies, was usually associated with clear evidence of vitamin B12 or folic acid deficiency. Moreover, this seemed to be so even when the megaloblastic transformation of erythropoiesis was not well developed. With further experience...
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ژورنال
عنوان ژورنال: Journal of Clinical Pathology
سال: 1961
ISSN: 0021-9746
DOI: 10.1136/jcp.14.4.374